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Vertex (TM) Pharmaceuticals Incorporated, founded in 1989 and based in Cambridge, Massachusetts, develops small molecule drugs that treat cancer, HIV, hepatitis, arthritis, cystic fibrosis, pain, and other diseases and medical conditions. Drug discovery research focuses on human protein kinase inhibitors and ion channels. The company has worked with Merck & Company, GlaxoSmithKline (GSK), Avalon Pharmaceuticals, Novartis Pharma AG, Schering AG, and other companies in developing drugs. It has worked with GSK since 1993. The collaboration produced the Lexiva (R) and Agenerase (R) HIV protease inhibitors. Vertex Pharmaceuticals began working with Merck in 2004. The companies have developed the VX-680 cancer treatment. Vertex Pharmaceuticals maintains additional offices in San Diego, California and Oxfordshire, England. The company went public in 1991. It is listed on NASDAQ under the VRTX symbol.
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