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Genstruct Incorporated, founded in 2002 and based in Cambridge, Massachusetts, is a privately held company that develops real-time biological research systems and methodologies that optimize mechanism-based drug discovery processes. The firm markets its systems and services to clients across the pharmaceutical and biotechnology sectors. The company is known for its Knowledge Assembly (R) models, mechanisms, and biomarkers. The firm's proprietary platform is built on a large-scale causal modeling methodology. It supports the modeling of biological systems at the cell, tissue, and organ levels. The platform allows Genstruct life scientists to build Causal System (TM) Models of diseases and drug actions. Models are employed in defining disease mechanisms, drug activity and toxicity mechanisms, and mechanistic biomarkers. Processing begins with human, rat, and mouse Knowledge Assembly models. The models can be customized. The firm has focused on developing oncology, metabolic disease, and inflammation model sets. Genstruct was founded by Navin Chandra, Noubar Afeyan, and Keith Elliston.
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Information Sources, Inc.