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Article

Title: OCT Images the Developing Heart In Vivo

Author: Jenkins, Michael W; Rollins, Andrew M Article Type: Product Analysis
Source: Laser Focus World, v43 n11 p77(4) Publication Date: Nov 2007
  ISSN: 0740-2511
  Illustrations: Photographs
URL of Publication: http://www.lfw.com

A study by Case Western Reserve University shows that optical-coherence tomography (OCT) imaging is well suited to examining and phenotyping the living, breathing, developing heart, a key to understanding the development of congenital heart disease. OCT imaging can assess the 3-D morphology of the embryonic heart much more rapidly than by histology, and without destroying the sample. It measures coherently back-scattered light to generate cross-sectional images of biological tissue. Because OCT is capable of very high imaging rates, it offers the ability to examine tissue morphology dynamically, as well as statically. Members of the research team developed cardiac-gating methods to build up 4-D image sets over mouse heartbeats and constructed an OCT system featuring a Fourer-domain modelocked laser (FDML). The FDML lasers have enabled unprecedented OCT imaging speeds, enabling the acquisition of high-temporal-resolution 2-D image sets (195 frames per second) and 3-D datasets (10 volumes per second). The FDML laser OCT system allowed an 'in vivo' image of a preseptated embryonic avian heart, without the aid of gating, for the first time. It was also the first time the embryonic heart could be viewed in cross section during looping with extremely high temporal resolution.

Special Features: Photographs

Products:
Cardiology OCT (Optical Coherence Tomography)

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