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Article

Title: A Combined Experimental/Predictive Approach To Toxicity

Author: Milczarek, Robert; Prewitt IV, John M; Kelly, James H... Article Type: Product Analysis
Source: BioScience Technology, v31 n7 p22(2) Publication Date: Jul 2006
  ISSN: 0192-1266
  Illustrations: Graphs, Screen Layouts
URL of Publication: http://www.biosciencetechnology.com

The ACTIVTox system can be combined with MDL Assay Explorer and other Elsevier MDL software to create a system for predictive hepatotoxicology. Such a system could significantly help reduce the time and costs involved in drug discovery since it addresses the issues of liver toxicity in the drug development process. ACTIVTox, from Amphioxus Cell Technologies (now Stem Cell Innovations), offers a hepatocyte-based system for predictive toxicology such as lactate dehydrogenase (LDH) release. This system works well when combined with Elsevier MDL software, which includes a MDL Assay Explorer module. MDL Assay Explorer manages the collection and visualization of screening campaigns. With the help of other Elsevier MDL software, a database can be built to help during the drug discovery process to determine and eliminate hepatoxicity. The combination can help evaluate the structural framework of liver toxicity. In an experiment using ACTIVTox with Elsevier MDL software, user-generated data were incorporated to create a customized environment for lead optimization. Data from the readers were collected and plotted by the MDL Assay Explorer. From here, compound information and structure are shown to help identify known and unknown inducers of cyp1A.

Special Features: Graphs, Screen Layouts

Companies:
MDL Information Systems Inc Stem Cell Innovations

Products:
ACTIVTox Cell Based Assays
MDL Assay Explorer Toxicology

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