Eksigent's Microfluidic Flow Control pump technology eliminates the flow splitters found in conventional High Performance Liquid Chromatography (HPLC) instruments so that researchers can instantly adjust flow rates for more accurate, consistent, and precise analyses. New drivers can be integrated with Thermo Electron's Xcalibur and Applied Biosystems/MDS/Sciex's Analyst 1.4.1 mass spectrometer platforms. Users can run the ExpressLC-100 and the mass spectrometer as a single integrated system. Micro-Tech Scientific's X'TremeSimple system provides precise low-volume control without use of splitters. The system is compatible with the Xcalibur and Analyst platforms and can be used for nano-LC-MS, capillary-LC-MS, proteomics drug discovery, protein drug quality control, and automated microtiter plate sample preparation for matrix-assisted laser desorption/ionization time of mass spectroscopy (MALDI-MS). Micro-Tech also offers the Ultra-Plus, which is a microflow product similar to the Eksigent ExpressLC system. Agilent's 1100 Series HPLC and Capillary LC systems include the 1100 Series capillary pump with an electronic flow control. The 1100 Series can be combined with Agilent's mass spectrometry products for analysis of very small samples and very low analyte concentrations that are intrinsic to many proteomic applications. Similar systems from Waters that are highlighted are the Acquity UPLC and nanoAcquity UPLC.