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Article

Title: Ultrafast laser pulses combine the benefits of optical and...

Author: Hogan, Hank Article Type: Product Analysis
Source: Biophotonics International, v12 n8 p61(3) Publication Date: Aug 2005
  ISSN: 1081-8693
  Illustrations: Output Samples
URL of Publication: http://www.photonics.com

At the California Institute of Technology, researchers have demonstrated a device that combines the spatial resolution of electron microscopy with the temporal resolution of optical microscopy. The combination was made possible through the integration of an optical system driven by a femtosecond laser with a transmission electron microscope. The combined device has a femtosecond time resolution and is capable of imaging angstrom-scale biological features. Electronic microscopy provides an important advantage over its optical counterpart. In contrast to optical microscopy, imaging speeds that are not available with electron-based techniques are possible. Optical techniques, including fluorescence microscopy, allow researchers to image events and transients at a high speed. To build the ultrafast electronic microscope, the researchers at Caltech began with a standard TEM from FEI. They added two ports to allow injection of two pulsed laser beams (one near the sample and the other close to the cathode). A new and different electron production scheme used included a diode-pumped, mode-locked Ti:sapphire laser oscillator and optical system to produce two teams. Tests show that the electron source for the ultrafast electron microscope worked as well for imaging as did the more standard one used in the TEM. Some differences are described. A team member predicts that the ultrafast, electron microscope will be used to image dynamic events in materials and biological cells.

Special Features: Output Samples

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Electron Microscopy Optical Microscopy

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