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Article

Title: Nanosensor detects Alzheimer's

Author: Van Duyne, R P Article Type: Product Analysis
Source: MICRO/NANO, v9 n6 p18(1) Publication Date: Jun 2004
  ISSN: 1099-7741
  Illustrations: Charts

Bill Klein and Richard Van Duyne of Northwestern University have developed a localized surface plasmon resonance (LSPR) nanosensor that views molecules that could be 'involved in the development of Alzheimer's disease.' The sensors view interaction between amyloid-B-derived diffusible ligands (ADDL) and the anti-ADDL antibody. It is not hypothesized that amyloid-B can self-assemble into soluble oligomers (ADDLs) and into plaques. ADDL levels have been shown to be elevated in brain samples from people with Alzheimer's. Therefore, a test that measures ADDL levels in body fluids could become a diagnostic tool for the disease. The LSPR nanosensor is two or more times more sensitive than the assays developed by the term earlier. The refractive index-based sensing device leverages the unusually optical properties of nanoparticles of metals such as silver, gold, and copper. Conduction electrons in the particles can oscillate collectively as response to specific wavelengths of light and can be monitored easily via ultraviolet-visible (UV-vis) spectroscopy. Nanosphere lithography is used to make the nanosensor. The research team is working with Merck to develop therapeutics that target ADDLs.

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